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Oxazolidinones as Novel Human CCR8 Antagonists.

โœ Scribed by Jian Jin; et al. et al.

Book ID
102005873
Publisher
John Wiley and Sons
Year
2007
Weight
13 KB
Volume
38
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Abstract

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๐Ÿ“œ SIMILAR VOLUMES

Novel pyrrolidine heterocycles as CCR1 a
Novel pyrrolidine heterocycles as CCR1 antagonists
โœ J. Robert Merritt; Ray James; Vidyadhar M. Paradkar; Chongwu Zhang; Ruiyan Liu; ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 239 KB

A novel series of pyrrolidine heterocycles was prepared and found to show potent inhibitory activity of CCR1 binding and CCL3 mediated chemotaxis of a CCR1-expressing cell line. A potent, optimized triazole lead from this series was found to have acceptable pharmacokinetics and microsomal stability