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Oxazolidinone antibacterial agents: development of the clinical candidates eperezolid and linezolid

โœ Scribed by Zurenko, Gary E; Ford, Charles W; Hutchinson, Douglas K; Brickner, Steven J; Barbachyn, Micheal R

Book ID
120821460
Publisher
Informa plc
Year
1997
Tongue
English
Weight
156 KB
Volume
6
Category
Article
ISSN
1354-3784

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ChemInform Abstract: A Short Synthesis of Oxazolidinone Derivatives Linezolid and Eperezolid: A New Class of Antibacterials.
โœ Braj B. Lohray; Sundarababu Baskaran; B. Srinivasa Rao; B. Yadi Reddy; I. Negesw ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 31 KB ๐Ÿ‘ 2 views

Starting from the D-mannitol derivative (I), a straightforward synthesis of the chiral oxazolidines (VII) including precursors (VIIb) and (VIIc) of linezolid and eperezolid is detailed. Furthermore, the azide (VIIb) is converted to linezolid (IX) with thioacetic acid.