Oxazine- and oxazole-fused derivatives of the alkaloid boldine and their complete structural and spectral assignments by HMQC and HMBC experiments

✍ Scribed by Eduardo Sobarzo-Sánchez; Bruce K. Cassels; Claudio Saitz-Barría; Carolina Jullian

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 117 KB
• Volume: 39
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.852

✦ Synopsis

Abstract

The novel heterocycles 1,11‐dimethoxy‐2‐hydroxy‐6‐methyloxazolo[4,5‐k]‐5,6,6a,7‐tetrahydro‐4__H__‐dibenzo [de,g]quinoline, 1,12‐dimethoxy‐2‐hydroxy‐6‐methyl‐9‐phenyl‐10__H__‐oxazin[5,6‐k]‐5,6,6a,7‐tetrahydro‐4__H__‐ dibenzo[de,g]quinolin‐10‐one and 1,11‐dimethoxy‐2‐hydroxy‐6‐methyl‐9‐phenyloxazolo[4,5‐k]‐5,6,6a,7‐tetrahydro‐4__H__‐dibenzo[de,g]quinoline were prepared starting from the alkaloid boldine. The structures were confirmed and the ^1^H and ^13^C NMR spectra were completely assigned using a combination of one‐ and two‐dimensional NMR techniques. Copyright © 2001 John Wiley & Sons, Ltd.