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Overexpression ofbaxenhances the radiation sensitivity in human breast cancer cells

✍ Scribed by Chouhei Sakakura; Elizabeth A. Sweeney; Tsutomu Shirahama; Yasuyuki Igarashi; Sen-Ichiroh Hakomori; Hiroyuki Tsujimoto; Tsutomu Imanishi; Masaharu Ohgaki; Junya Yamazaki; Akeo Hagiwara; Kiyoshi Sawai; Toshiharu Yamaguchi; Toshio Takahashi


Book ID
112527443
Publisher
Springer
Year
1997
Tongue
English
Weight
485 KB
Volume
27
Category
Article
ISSN
1436-2813

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Resistance to apoptosis plays an important role in tumors that are refractory to chemotherapy and ionizing radiation (IR). bax, which forms a heterddimer with bcl-2 and accelerates apoptosir, is not, or only weakly. expremed in most human breast cancer cells, and weak bax expression is considered to

Effect of p53 overexpression on radiatio
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Substantial controversy surrounds our understanding of the effect of p53 status on radiation sensitivity. To assess directly the role of p53 expression on radiation sensitivity, we chose a conditional expression system using a temperature-sensitive murine p53 that permitted each cell line to act as