Vascular endothelial growth factor-C (VEGF-C) has been shown to promote survival and resistance to chemotherapy of AML-cells in vitro. We investigated the expression of VEGF-C/VEGFR-3 in the bone marrow and pretherapeutic plasma levels of VEGF-C in patients with newly diagnosed AML. Expression of VE
✦ LIBER ✦
Overexpression of vascular endothelial growth factor (VEGF) and its cellular receptor KDR (VEGFR-2) in the bone marrow of patients with acute myeloid leukemia
✍ Scribed by Padró, T; Bieker, R; Ruiz, S; Steins, M; Retzlaff, S; Bürger, H; Büchner, T; Kessler, T; Herrera, F; Kienast, J
- Book ID
- 110055099
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 287 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0887-6924
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The formation of new vessels (angiogenesis) is essential for primary tumour growth and metastasis and is induced by several angiogenic factors, including vascular endothelial growth factor (VEGF). The microvascular density (MVD) in tumours was assessed and the expression of VEGF and its receptors VE