Overexpression of the wild type p73 gene in human bladder cancer
β Scribed by Yokomizo, Akira; Mai, Ming; Tindall, Donald J; Cheng, Liang; Bostwick, David G; Naito, Seiji; Smith, David I; Liu, Wanguo
- Book ID
- 110061922
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 206 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0950-9232
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In primary breast cancer, mutations of the p53 tumor suppressor gene lead to loss of growth-suppressive properties and poor outcome. Recently, a p53-related gene, termed p73, has been cloned and its gene product possesses a function similar to p53. p73 has been mapped at chromosome 1p36.3, a region
Retroviral vectors were used to introduce the wild-type p53 gene into human bladder cancer cell lines BIU-87 and EJ, which express endogenous wt-p53 gene and have a mutation in H-ras gene. The expression of the exogenous wt-p53 gene in cells suppresses the growth of the bladder cancer cells in stand