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Overexpression of the mouse Fas gene in human Hep3B hepatoma cells overcomes their resistance to Fas-mediated apoptosis

✍ Scribed by Christelle Lamboley; Annie-France Bringuier; Emmanuel Camus; Bernard Lardeux; André Groyer; Gérard Feldmann


Book ID
119526796
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
491 KB
Volume
36
Category
Article
ISSN
0168-8278

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## Abstract It is important for more effective gene therapies to clarify the mechanisms by which cDNA integrated into cells can maintain or lose its function __in vivo__. We evaluated genetic and epigenetic events leading to alternation of the introduced CD95 (Fas/Apo‐1) gene as a model of gene the