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Overexpression of the Human Lysosomal Enzyme α-L-Iduronidase in Chinese Hamster Ovary Cells

✍ Scribed by E.D. Kakkis; A. Matynia; A.J. Jonas; E.F. Neufeld


Book ID
115644827
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
784 KB
Volume
5
Category
Article
ISSN
1046-5928

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## Abstract To improve the production of recombinant human antithrombin III (AT‐III) in Chinese hamster ovary (CHO) cells, the genes encoding transcription factors, ATF4 (activating transcription factor 4) and XBP‐1s (the spliced form of X‐box binding protein 1), which were involved in the mammalia