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Overexpression of GADD34 Enhances Production of Recombinant Human Antithrombin III in Chinese Hamster Ovary Cells

✍ Scribed by Takeshi Omasa; Takashi Takami; Tomoshi Ohya; Eriko Kiyama; Tetsuji Hayashi; Hiroko Nishii; Hideo Miki; Kaoru Kobayashi; Kohsuke Honda; Hisao Ohtake

Book ID
118729479
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
447 KB
Volume
106
Category
Article
ISSN
1389-1723

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Overexpression of recombinant proteins in animal cells is commonly achieved by using gene amplification techniques. Gene amplified cells possess up to several thousand genes coding for the target protein. Constitutive expression of these genes leads to high levels of the corresponding mRNA species