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Overexpression of Snail induces epithelial–mesenchymal transition and a cancer stem cell–like phenotype in human colorectal cancer cells

✍ Scribed by Fan Fan; Shaija Samuel; Kurt W. Evans; Jia Lu; Ling Xia; Yunfei Zhou; Eric Sceusi; Federico Tozzi; Xiang-Cang Ye; Sendurai A. Mani; Lee M. Ellis

Book ID
112015818
Publisher
Wiley (John Wiley & Sons)
Year
2012
Tongue
English
Weight
539 KB
Volume
1
Category
Article
ISSN
2045-7634

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## Abstract Cancer stem cells (CSCs) are similar to normal stem cells in their ability to self‐renew and to generate large populations of more differentiated descendants. In contrast to the hierarchical organization that is presumed to be the prevalent mode of normal tissue homeostasis, phenotypic