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Overexpression of secreted frizzled-related protein 1 inhibits bone formation and attenuates parathyroid hormone bone anabolic effects

✍ Scribed by Wei Yao; Zhiqiang Cheng; Mohammad Shahnazari; Wewei Dai; Mark L Johnson; Nancy E Lane


Book ID
111485804
Publisher
American Society for Bone and Mineral Research
Year
2009
Tongue
English
Weight
280 KB
Volume
25
Category
Article
ISSN
0884-0431

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## Abstract Secreted frizzled‐related protein (sFRP)‐1 is a Wnt antagonist that when deleted in mice leads to increased trabecular bone formation in adult animals after 13 weeks of age. Treatment of mice with parathyroid hormone (PTH) also increases trabecular bone formation, and some of the anabol