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Overexpression of phospholipase C-γ1 suppresses UVC-induced apoptosis through inhibition of c-fos accumulation and c-Jun N-terminal kinase activation in PC12 cells

✍ Scribed by Young Han Lee; Seong-Yong Kim; Jae-Ryong Kim; Ki Young Kim; Myung Jong Kim; Sung Ho Ryu; Pann-Ghill Suh; Jung-Hye Kim


Book ID
117772599
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
444 KB
Volume
1440
Category
Article
ISSN
1388-1981

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Human monocytic leukemia U937 cells undergo apoptosis when treated with antitumor drugs, such as etoposide, camptothecin and mitomycin C. The molecular mechanism of the drug-induced apoptosis is not well understood. In this study, we found that 2-deoxyglucose (2DG), an analog of D-glucose and an ind