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p44/42 MAP kinase and c-Jun N-terminal kinase contribute to the up-regulation of caspase-3 in manganese-induced apoptosis in PC12 cells

✍ Scribed by Yoshimasa Ito; Kentaro Oh-hashi; Kazutoshi Kiuchi; Yoko Hirata

Book ID: 113501679
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 493 KB
Volume: 1099
Category: Article
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2006.03.126

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## Abstract Protein kinase C (PKC), a family of serine‐threonine kinases, has been implicated in the regulation of colon tumorigenesis. However, the specific isoform of PKC involved in this process is not clear. In the present study, we found that treatment of the cultured human colon cancer cell l