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Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions

โœ Scribed by Brian T. Feeley; Lucie Krenek; Nancy Liu; Wellington K. Hsu; Seth C. Gamradt; Edward M. Schwarz; Johnny Huard; Jay R. Lieberman

Book ID
116319258
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
632 KB
Volume
38
Category
Article
ISSN
8756-3282

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## Abstract Matrix metalloproteinases (MMPs) are proteolytic enzymes that play critical roles in the pathogenesis of human cancers. Clinical trials using synthetic small molecule MMP inhibitors have been carried out but with little success. Tissue inhibitors of metalloproteinases (TIMPs) are endoge