Mouse coding region determinant-binding (mCRD-BP) and human IGF-II mRNA-binding 1 (hIMP-1) proteins are orthologous mRNA-binding proteins that recognize c-myc and IGF-II mRNA, respectively, and regulate their expression posttranscriptionally. Here, we confirm that human CRD-BP/IMP-1 binds to c-myc m
Overexpression of mRNA-binding protein CRD-BP in malignant melanomas
β Scribed by Spiegelman, V S; Elcheva, I; Tarapore, R S; Bhatia, N
- Book ID
- 109970459
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 296 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0950-9232
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## Abstract The oncofetal CRDβBP/IMP1 RNA binding protein regulates posttranscriptionally a handful of RNA transcripts, implicated in cell adhesion and invadopodia formation and was recently identified as a target of the Ξ²βcatenin/Tcf transcription factor that is constitutively activated in colorec
## Abstract The coding region determinant binding protein (__CRDβBP__) was isolated by virtue of its high affinity to the cβ__myc__ mRNA coding region stability determinant and shown to shield this message from nucleolytic attack, prolonging its halfβlife. __CRDβBP__ is normally expressed during fe