C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors

✍ Scribed by Panayotis Ioannidis; Theoni Trangas; Euthymios Dimitriadis; Martina Samiotaki; Ioannis Kyriazoglou; Chris M. Tsiapalis; Christos Kittas; Niki Agnantis; Finn Cilius Nielsen; Jacob Nielsen; Jan Christiansen; Nikos Pandis

• Book ID: 102270154
• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: French
• Weight: 168 KB
• Volume: 94
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.1512

✦ Synopsis

Mouse coding region determinant-binding (mCRD-BP) and human IGF-II mRNA-binding 1 (hIMP-1) proteins are orthologous mRNA-binding proteins that recognize c-myc and IGF-II mRNA, respectively, and regulate their expression posttranscriptionally. Here, we confirm that human CRD-BP/IMP-1 binds to c-myc mRNA and that it is predominantly expressed in fetal tissues. Moreover, hCRD-BP/IMP-1 expression was detected in cell lines of neoplastic origin and in selected primary tumors. In a series of 33 malignant and 10 benign mesenchymal tumors, 73% and 40%, respectively, were found to express hCRD-BP/IMP-1. In particular, expression was significant in 14 Ewing's sarcomas, all of which were positive. The data suggest that hCRD-BP/IMP-1 plays a role in abnormal cell proliferation in mesenchymal tumors.