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Overexpression of microRNAs enhances recombinant protein production in Chinese hamster ovary cells

✍ Scribed by Loh, Wan Ping; Loo, Bernard; Zhou, Lihan; Zhang, Peiqing; Lee, Dong-Yup; Yang, Yuansheng; Lam, Kong Peng

Book ID
123616556
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
635 KB
Volume
9
Category
Article
ISSN
1860-6768

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## Abstract To improve the production of recombinant human antithrombin III (AT‐III) in Chinese hamster ovary (CHO) cells, the genes encoding transcription factors, ATF4 (activating transcription factor 4) and XBP‐1s (the spliced form of X‐box binding protein 1), which were involved in the mammalia