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Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis

✍ Scribed by Ichikawa, Tomonaga; Kitajima, Shuji; Liang, Jingyan; Koike, Tomonari; Wang, Xiaofei; Sun, Huijun; Okazaki, Mitsuyo; Morimoto, Masatoshi; Shikama, Hisataka; Watanabe, Teruo

Book ID: 109885746
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 610 KB
Volume: 84
Category: Article
ISSN: 0023-6837
DOI: 10.1038/labinvest.3700102

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Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles

✍ Tomonari Koike; Xiaofei Wang; Hiroyuki Unoki; Jingyan Liang; Tomonaga Ichikawa; 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 306 KB

## Abstract Lipoprotein lipase (LPL) plays an important role in plasma lipoprotein metabolism and the uptake of free fatty acid in muscle. Previous studies using transgenic mice showed that increased LPL leads to myopathies, but these results were controversial. To examine this hypothesis, we studi