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Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles

✍ Scribed by Tomonari Koike; Xiaofei Wang; Hiroyuki Unoki; Jingyan Liang; Tomonaga Ichikawa; Shuji Kitajima; Teruo Watanabe; Jianglin Fan

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 306 KB
Volume: 26
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.10282

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✦ Synopsis

Abstract

Lipoprotein lipase (LPL) plays an important role in plasma lipoprotein metabolism and the uptake of free fatty acid in muscle. Previous studies using transgenic mice showed that increased LPL leads to myopathies, but these results were controversial. To examine this hypothesis, we studied LPL transgenic rabbits, and our results refute the suggested role of LPL in the pathogenesis of myopathies. © 2002 Wiley Periodicals, Inc. Muscle Nerve 26: 823–827, 2002

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