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Overexpression of intestinal trefoil factor in human colon carcinoma cells reduces cellular growth in vitro and in vivo

✍ Scribed by Hirofumi Uchino; Hiroaki Kataoka; Hiroshi Itoh; Ryouichi Hamasuna; Masashi Koono

Book ID
119424159
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
422 KB
Volume
118
Category
Article
ISSN
0016-5085

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## Abstract ## BACKGROUND High concentrations of insulin‐like growth factor (IGF)‐I and IGF‐II have been demonstrated in human colonic adenocarcinomas and exert mitogenic effects through paracrine/autocrine interactions with the IGF‐I receptor (IGF‐IR). However, definitive studies of IGF‐IR expres