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Overexpression of Ha-ras enhances the transcription of human arachidonate 12-lipoxygenase promoter in A431 cells

โœ Scribed by Ben-Kuen Chen; Yi-Wen Liu; Shozo Yamamoto; Wen-Chang Chang


Book ID
117049411
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
264 KB
Volume
1344
Category
Article
ISSN
0005-2760

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Results from nuclear run-off assays show that exposure of hepatocytes and Reuber H35B hepatoma cells to the tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), leads to enhanced transcription of c-Ki-ras gene. This increase in transcription in turn results in an accumulation of the function