Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cells
✍ Scribed by Jens Pahnke; Eilhard Mix; Rupert Knoblich; Jana Müller; Marlies Zschiesche; Beke Schubert; Dirk Koczan; Peter Bauer; Tobias Böttcher; Hans-Jürgen Thiesen; Ludmil Lazarov; Andreas Wree; Arndt Rolfs
- Book ID
- 116981003
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 498 KB
- Volume
- 297
- Category
- Article
- ISSN
- 0014-4827
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Human SK-N-AS neuroblastoma and U-87MG glioblastoma cell lines were found to secrete relatively high levels of glial cell line-derived neurotrophic factor (GDNF). In response to growth factors, cytokines, and pharmacophores, the two cell lines differentially regulated GDNF release. A 24-hr exposure
## Abstract Much attention has been paid to the ability of glial cell line‐derived neurotrophic factor (GDNF) to protect neurons from neurotoxic insults in the central nervous system (CNS). However, little is known about GDNF action on CNS glia that also can express GDNF receptor systems. In this s