Differential in Vivo Effects of Neurturin and Glial Cell-Line-Derived Neurotrophic Factor
โ Scribed by Michael R. Hoane; Amit G. Gulwadi; Sharon Morrison; Ginny Hovanesian; Mark D. Lindner; Weng Tao
- Book ID
- 115607068
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 139 KB
- Volume
- 160
- Category
- Article
- ISSN
- 0014-4886
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The c-ret protooncogene, RET, encodes a receptor tyrosine kinase. RET is activated by members of the glial cell line-derived neurotrophic factor (GDNF) family of ligands, which include GDNF, neurturin, artemin, and persephin. The ligands bind RET through GDNF family receptor alpha, termed GFRalpha1-
Glial cell line-derived neurotrophic factor (GDNF) was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is a more potent survival factor for dopaminergic neurons and the noradrenerg