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Overexpression of ErbB-2 Protein in Human Middle Ear Cholesteatomas

✍ Scribed by Takashi Sakamoto; Kenji Kondo; Tatsuya Yamasoba; Mitsuya Suzuki; Masashi Sugasawa; Kimitaka Kaga

Book ID
110087470
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
645 KB
Volume
114
Category
Article
ISSN
0023-852X

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## Abstract The c‐__erb__B‐2/__neu__ gene encodes a transmembrane protein of 185 kDa (p185) with tyrosine kinase activity and extensive sequence homology to epidermal growth factor receptor. Amplification and overexpression of the c‐__erb__B‐2/__neu__ gene has been shown in certain human tumors and