## Abstract Insulin receptor substrate 1 (IRSโ1) is a major downstream signaling protein for insulin and insulinโlike growth factor I (IGFโI) receptors, conveying signals to PIโ3K/Akt and ERK1/2 pathways. In breast cancer, IRSโ1 overexpression has been associated with tumor development, hormoneโind
โฆ LIBER โฆ
Overexpression of cyclin D1 enhances taxol induced mitotic death in MCF7 cells
โ Scribed by Rob Michalides; Machteld Tiemessen; Tom Verschoor; Astrid Balkenende; Jose Coco-Martin
- Book ID
- 110345131
- Publisher
- Springer US
- Year
- 2002
- Tongue
- English
- Weight
- 209 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0167-6806
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## Abstract Cyclin D1 plays a pivotal role in cellโcycle transition through G1 phase. In this article, we found that Degenerative Spermatocyte Homolog 1 (DEGS1) upโregulated the expression of cyclin D1 and the activation of transcription factor NFโฮบB was essential for DEGS1โinduced cyclin D1 produc