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Overexpression and substrate specificity studies of phosphodeoxyribomutase and thymidine phosphorylase

✍ Scribed by Carlos F. Barbas III; Chi-Huey Wong

Book ID
107873831
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
550 KB
Volume
19
Category
Article
ISSN
0045-2068

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To compare the activity of pyrimidine nucleoside phosphorylase (PNP), an enzyme involved in the metabolism of 5-fluorouracil (5-FU), we used uridine (Urd), deoxyuridine (dUrd), and thymidine (dThd) as substrates and human, rat, and mouse neoplastic and normal tissues. As PNP activity was higher in t