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Substrate specificity and molecular modelling of the feline herpesvirus-1 thymidine kinase

✍ Scribed by Islam T. M. Hussein; Ricardo Núñez Miguel; Laurence S. Tiley; Hugh J. Field


Publisher
Springer Vienna
Year
2008
Tongue
English
Weight
531 KB
Volume
153
Category
Article
ISSN
1432-8798

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The enzyme herpes simplex virus type 1 thymidine kinase (HSV1 TK) salvages thymidine into the DNA metabolism of the virus. In the active site, the thymine ring of the nucleoside binds in a pocket, formed by two residues, Tyr-172 and Met-128, in a sandwich-type orientation. To investigate the nature