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Overcoming acetate in Escherichia coli recombinant protein fermentations

✍ Scribed by Mark A. Eiteman; Elliot Altman


Book ID
113932021
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
464 KB
Volume
24
Category
Article
ISSN
0167-7799

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The productivity of Escherichia coli as a producer of recombinant proteins is affected by its metabolic properties, especially by acetate production. Two commercially used E. coli strains, BL21 (DE3) and JM109, differ significantly in their acetate production during batch fermentation at high initia