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Over-production of IFN-γ and IL-12 in AhR-null mice

✍ Scribed by Miriam Rodríguez-Sosa; Guillermo Elizondo; Rosa María López-Durán; Irma Rivera; Frank J. Gonzalez; Libia Vega


Book ID
116466119
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
241 KB
Volume
579
Category
Article
ISSN
0014-5793

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Phytohemagglutinin (PHA)-derived T lymphoblasts or T cell clones from patients genetically deficient in IL-12R g 1 (IL-12R g 1 -/-) or IFN-+ R1 (IFN-+ R1 -/-) produced two-to threefold reduced IFN-+ levels compared to the corresponding cells from healthy individuals after anti-CD3 and PMA stimulatio