Regulation of interferon-γ production by
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Haruki Okamura; Shin-ichiro Kashiwamura; Hiroko Tsutsui; Tomohiro Yoshimoto; Ken
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Article
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1998
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Elsevier Science
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English
⚖ 566 KB
IL-18 (interferon-inducing factor) and IL-12 exhibit a marked synergism in interferon-gamma induction in T cells. Investigations into the mechanism of this synergism have revealed that IL-12 upregulates expression of the IL-18 receptor on cells producing interferon-gamma. Although IL-18 does not ind