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IL-18 receptor induction by IL-12 in the chicken: IL-12 and IL-18 synergistically stimulate IFN-γ production

✍ Scribed by Jesse D. Thomas; Dale I. Godfrey; John W. Lowenthal; Andrew G.D. Bean


Book ID
116966367
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
93 KB
Volume
128
Category
Article
ISSN
0165-2427

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✍ Haruki Okamura; Shin-ichiro Kashiwamura; Hiroko Tsutsui; Tomohiro Yoshimoto; Ken 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 566 KB

IL-18 (interferon-inducing factor) and IL-12 exhibit a marked synergism in interferon-gamma induction in T cells. Investigations into the mechanism of this synergism have revealed that IL-12 upregulates expression of the IL-18 receptor on cells producing interferon-gamma. Although IL-18 does not ind