## Abstract We have analyzed the __BCL1__ locus in a series of 24 Bβcell tumors and cell lines with rearrangements of 11q13 (mostly t(11;14)(q13;q32) translocations). Using Southern hybridization and/or fluorescence in situ hybridization (FISH) on metaphase chromosomes, we have not only confirmed t
Over-expression of cyclin D1 in chronic B-cell malignancies with abnormality of chromosome 11q13
β Scribed by Alain Delmer; Florence Ajchenbaum-Cymbalista; Ruoping Tang; Sylvie Ramond; Anne-Marie Faussat; Jean-Pierre Marie; Robert Zittoun
- Book ID
- 114714478
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 714 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0007-1048
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The cyclin-D1/PRAD1 oncogene, a key regulator of the G 1 -phase progression of the cell cycle, has been identified as the long-sought BCL-1 oncogene in B-cell malignancies with t(11;14)(q13;q32) translocation. A novel alternative spliced cyclin-D1 transcript, called transcript[b], has been identifie
## Abstract Eight cytogenetically characterized head and neck squamous cell carcinomas (HNSCCs) with __CCND1__ amplification in the form of a homogeneously staining region (hsr) in 11q13 were studied by COBRA FISH and FISH with specific probes to identify and characterize chromosomal segments added