Hairy cell leukemia with translocation (11;20)(q13;q11) and overexpression of cyclin D1
β Scribed by Fumihiro Ishida; Kiyoshi Kitano; Naoaki Ichikawa; Toshiro Ito; Youichi Kohara; Toshiyasu Taniguchi; Toru Motokura; Kendo Kiyosawa
- Book ID
- 114119611
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 210 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0145-2126
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We present a 6-year-old girl with a balanced 11;20 translocation [46,XX,t(11;20)(q13.1; q13.13)patl, asplenia, pulmonic stenosis, Hirschsprung disease, minor anomalies, and mental retardation. This case represents the second report of an individual with situs abnormalities and a balanced chromosome
The cyclin-D1/PRAD1 oncogene, a key regulator of the G 1 -phase progression of the cell cycle, has been identified as the long-sought BCL-1 oncogene in B-cell malignancies with t(11;14)(q13;q32) translocation. A novel alternative spliced cyclin-D1 transcript, called transcript[b], has been identifie