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Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1

✍ Scribed by Ian Harley; Barry Rosen; Harvey A. Risch; Kathy Siminovitch; Mario E. Beiner; John McLaughlin; Ping Sun; Steven A. Narod

Book ID
113961461
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
130 KB
Volume
109
Category
Article
ISSN
0090-8258

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## Communicated by Riccardo Fodde Numerous unclassified variants (UVs) have been found in the mismatch repair genes MLH1 and MSH2 involved in hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Some of these variants may have an effect on pre-mRNA splicing, either by altering dege