A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the prognosis of patients with ovarian cancer
โ Scribed by Lucia Six; Christoph Grimm; Sepp Leodolter; Clemens Tempfer; Robert Zeillinger; Gerhard Sliutz; Paul Speiser; Alexander Reinthaller; Lukas A. Hefler
- Book ID
- 113960241
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 147 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0090-8258
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The matrix metalloproteinases (MMPs) are a family of closely related proteolytic enzymes which are involved in the degradation of different components of the extracellular matrix. There is increasing evidence to indicate that individual MMPs have an important role in tumour invasion and tumour sprea
## Abstract Matrix metalloproteinases (MMPs) play an important role in several steps of cancer development. A single guanine insertion polymorphism (2G) in the __MMP1__ promoter sequence at โ1,607 creates an Ets binding site and thus results in enhancing transcriptional activity. This study aimed t