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Outfoxing liver cancer with p19ARF tumor suppressor?

✍ Scribed by Snorri S. Thorgeirsson

Book ID
102237820
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
399 KB
Volume
40
Category
Article
ISSN
0270-9139

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✦ Synopsis

Kuecblej, Yoder HM, etal. Foxml b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the ~1 9 ~~~ tumor suppressor. Genes Dev 2004;18:830-850. (Reprinted with permission of Genes & Development.

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## Abstract __p19__^__ARF__^ is a tumor suppressor that is frequently deleted in human cancer. It lies at chromosome 9p21 and shares exons 2 and 3 with __p16__^__ink4a__^, which is also inactivated by these cancer‐associated deletions. The β€œcanonical pathway” by which __p19__^__ARF__^ is thought to