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Monoclonal Antibodies to the Mouse p19Arf Tumor Suppressor Protein

✍ Scribed by Bertwistle, David; Zindy, Frederique; Sherr, Charles J.; Roussel, Martine F.

Book ID
111916816
Publisher
Mary Ann Liebert
Year
2004
Tongue
English
Weight
225 KB
Volume
23
Category
Article
ISSN
1536-8599

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## Abstract __p19__^__ARF__^ is a tumor suppressor that is frequently deleted in human cancer. It lies at chromosome 9p21 and shares exons 2 and 3 with __p16__^__ink4a__^, which is also inactivated by these cancer‐associated deletions. The β€œcanonical pathway” by which __p19__^__ARF__^ is thought to