Outcome of children and adolescents with relapsed acute lymphoblastic leukaemia and non-response to salvage protocol therapy: A retrospective analysis of the ALL-REZ BFM Study Group

Effective preventive central nervous sys

Effective preventive central nervous system therapy with extended triple intrathecal therapy and the modified ALL-BFM 86 chemotherapy program in an enlarged non-high risk group of children and adolescents with non-B-cell acute lymphoblastic leukemia : The ISRAEL National Study report

✍ Batia Stark; Rivka Sharon; Gideon Rechavi; Dina Attias; Ami Ballin; Gabriel Civi 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 145 KB 👁 2 views

BACKGROUND. Preventive cranial radiotherapy (CRT) in childhood acute lymphoblastic leukemia (ALL), although effective, may be associated with neurologic sequelae and second malignancies. Attempts to replace CRT with intensified intrathecal therapy (IT) have shown promise in lower risk subgroups. In