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Ototoxicity of aminoglycosides correlated with their action on monomolecular films of polyphosphoinositides

✍ Scribed by Shahid Lodhi; Norman D. Weiner; Iris Mechigian; Jochen Schacht

Book ID
115775240
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
623 KB
Volume
29
Category
Article
ISSN
0006-2952

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Lysine and polylysine: Correlation of their effects on polyphosphoinositides in vitro with ototoxic action in vivo
✍ Akira Takada; Shahid Lodhi; Norman D. Weiner; Jochen Schacht 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 207 KB

Low concentrations of poly-L-lysine, a polycationic hydrophilic molecule, caused a large expansion of polyphosphoinositide monolayers and produced a significant loss of cochlear microphonic potentials in perilymphatic perfusions in the guinea pig. In contrast, the monomeric L-lysine had only slight