✦ LIBER ✦

Lysine and polylysine: Correlation of their effects on polyphosphoinositides in vitro with ototoxic action in vivo

✍ Scribed by Akira Takada; Shahid Lodhi; Norman D. Weiner; Jochen Schacht

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 207 KB
Volume: 71
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600711226

No coin nor oath required. For personal study only.

✦ Synopsis

Low concentrations of poly-L-lysine, a polycationic hydrophilic molecule, caused a large expansion of polyphosphoinositide monolayers and produced a significant loss of cochlear microphonic potentials in perilymphatic perfusions in the guinea pig. In contrast, the monomeric L-lysine had only slight effects on polyphosphoinositide monolayers and did not affect cochlear microphonic potentials even at concentrations as high as 10 mM. These data substantiate the hypothesis that the expansion of polyphosphoinositide monolayers by a drug is an indicator of its ototoxicity.

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