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Osteoradionecrosis in Head-and-Neck Cancer Has a Distinct Genotype-Dependent Cause

✍ Scribed by Andrew J. Lyons; Catharine M. West; Janet M. Risk; Nick J. Slevin; Clara Chan; Siobhan Crichton; Gabrielle Rinck; Dawn Howell; Richard J. Shaw


Book ID
118455702
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
131 KB
Volume
82
Category
Article
ISSN
0360-3016

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## Abstract Cyclooxygenase‐2 (COX‐2) content is increased in many types of tumor cells. We have investigated the mechanism by which resveratrol, a stilbene that is pro‐apoptotic in many tumor cell lines, causes apoptosis in human head and neck squamous cell carcinoma UMSCC‐22B cells by a mechanism