Osteogenesis Depending on Geometry of Porous Hydroxyapatite Scaffolds
β Scribed by Masataka Yoshikawa; Norimasa Tsuji; Yasunori Shimomura; Hiroyuki Hayashi; Hajime Ohgushi
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 755 KB
- Volume
- 83
- Category
- Article
- ISSN
- 1432-0827
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In this work, the sintering and grain growth of hydroxyapatite green bodies are analyzed in order to identify the optimum heat treatments for the preparation of porous hydroxyapatite scaffolds. Sintering in air at temperatures ranging between 1100 and 1200 Β°C yields dense materials with narrow grain
Hydroxyapatite (HA) powder was prepared by wet chemical method. The hydroxyapatite phase was stable up to 1250 Β°C without decomposition to beta-tricalcium phosphate. Interconnected porous hydroxyapatite scaffold resembling trabecular bone structure was developed from polymeric replica sponge method.
## Abstract There is a need in tissueβengineering for 3D scaffolds that mimic the natural extracellular matrix of bone to enhance cell adhesion, proliferation, and differentiation. The scaffold is also required to be degradable. A highly porous scaffold has been developed to incorporate two of the