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Osteoclastic superoxide production and bone resorption: Stimulation and inhibition by modulators of NADPH oxidase

โœ Scribed by Alix G. Darden; William L. Ries; William C. Wolf; Ramona Marie Rodriguiz; L. Lyndon Key Jr.

Publisher
American Society for Bone and Mineral Research
Year
2009
Tongue
English
Weight
700 KB
Volume
11
Category
Article
ISSN
0884-0431

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โœฆ Synopsis

Production of superoxide radicals by osteoclasts is necessary for normal bone degradation. White blood cell superoxide, needed for bacterial killing, is produced by activated NADPH oxidase. Since osteoclasts and white blood cells share a common hematopoietic origin, we initiated experiments to test the hypothesis that superoxide radicals at the osteoclast-bone interface are produced by NADPH oxidase. Diphenyl iodonium (IDP), an inhibitor of NADPH oxidase, blocked superoxide generation and decreased osteoclastic bone resorption in cultures of calvarial explants from normal mice. Interferon (IFN) gamma, a stimulant of NADPH oxidase activity, increased superoxide production and bone resorption in cultures of calvarial explants from osteopetrotic (microphthalmic) mice. IDP blocked the stimulatory effects of IFN in this bone resorption model. These data suggest that osteoclastic superoxide is produced by NADPH oxidase. (

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