Long-term culture of disaggregated rat osteoclasts: Inhibition of bone resorption and reduction of osteoclast-like cell number by calcitonin and PTHrP[107-139]

Cellular mechanism of inhibition of oste

Cellular mechanism of inhibition of osteoclastic resorption of bone and calcified cartilage by long-term pamidronate administration in ovariectomized mature rats

✍ Mayahara, Mitsuori ;Sasaki, Takahisa 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 705 KB

## Abstract We examined the effects of long‐term bisphosphonate (BP, pamidronate) administration at a therapeutic dose (1.5 mg/kg/day) on the distribution, structure, and vacuolar‐type H^+^‐ATPase expression of osteoclasts, and the resulting trabecular bone volume and structure in ovariectomized (O