Osteoblast function in myeloma
β Scribed by G. David Roodman
- Book ID
- 116323566
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 357 KB
- Volume
- 48
- Category
- Article
- ISSN
- 8756-3282
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Multiple myeloma is the most common form of plasma cell dyscrasia and virtually all cases of myeloma exhibit osteolytic lesions, which result in bone pain, pathological fractures, spinal cord compression, and hypercalcaemia. Malignant plasma cells disrupt the delicate balance between bone formation
Myeloma behaves differently to other osteolytic tumours which metastasize to bone, in that the latter usually provoke reactive bone formation in the host bone. A previous study showed that a myeloma cell line (GM1500) secreted an osteoblast-inhibiting factor(s). The present study was undertaken to d