𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Myeloma affects both the growth and function of human osteoblast-like cells

✍ Scribed by Carol Elizabeth Evans; Carol Ward; Lakvinder Rathour; Charles Bernard Galasko

Publisher
Springer
Year
1992
Tongue
English
Weight
502 KB
Volume
10
Category
Article
ISSN
0262-0898

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✦ Synopsis

Myeloma behaves differently to other osteolytic tumours which metastasize to bone, in that the latter usually provoke reactive bone formation in the host bone. A previous study showed that a myeloma cell line (GM1500) secreted an osteoblast-inhibiting factor(s). The present study was undertaken to determine whether other myeloma cells also secreted a factor(s) which inhibited both cell proliferation and DNA synthesis of osteoblast-like cells and whether the myeloma also affected the function of osteoblasts. The results showed that a second cell line (Karpas 707) as well as myeloma tissue taken from two patients had a similar effect. The myeloma cells did not affect total collagen or protein synthesis, and did not affect the overall degree of mineralization. A biphasic effect was seen on alkaline phosphatase activity. Thus, although the proliferation of the pre-osteoblast was affected, the synthetic functions of the osteoblasts were not.

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