## Abstract In bone, mineralization is tightly regulated by osteoblasts and hypertrophic chondrocytes which release matrix vesicles (MVs) and control extracellular ionic conditions and matrix composition. MVs are the initial sites of hydroxyapatite (HA) mineral formation. Despite growing knowledge
✦ LIBER ✦
Proteomic characterization of biogenesis and functions of matrix vesicles released from mineralizing human osteoblast-like cells
✍ Scribed by Cyril Thouverey; Agata Malinowska; Marcin Balcerzak; Agnieszka Strzelecka-Kiliszek; René Buchet; Michal Dadlez; Slawomir Pikula
- Publisher
- Elsevier
- Year
- 2011
- Tongue
- English
- Weight
- 555 KB
- Volume
- 74
- Category
- Article
- ISSN
- 1874-3919
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## Abstract __Neuronal membrane glycoprotein gene__ (__GPM6B__) encodes a membrane glycoprotein that belongs to the proteolipid protein family. We identified __GPM6B__ as a gene that is strongly upregulated during osteoblast differentiation. To investigate the role of __GPM6B__ in the process of bo