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Osteoblast Adhesion and Proliferation on Poly(3-octylthiophene) Thin Films

✍ Scribed by Charlene Rincón; J. Carson Meredith

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
334 KB
Volume
10
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

In this study we assessed the suitability of semiconducting P3OT thin films (30 nm) to sustain attachment, spreading, and proliferation of MC3T3‐E1 osteoblasts. Cell area correlated with surface wettability: area was larger on the more hydrophilic surface (TCPS) and lower on the more hydrophobic surface (P3OT). Cells were rounder, characterized by higher circularity values, on TCPS and Si compared to P3OT. P3OT proliferation rate at 24 h fell twofold after 48 h, then recovered at 72 h to a value significantly higher than that on TCPS. Presoaking experiments showed no evidence of cytotoxic effects or leachants from P3OT. Overall, we conclude that P3OT is a viable substrate for osteoblast attachment and proliferation.

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are gratefully acknowledged. We also thank Dr. Tony Jenkins (Merck Chemicals Ltd.) for kindly providing one of the P3HT samples used in this study. Dr. Christian Chaumont is gratefully acknowledged for performing the XRD measurements on oriented TCB thin films. Supporting Information is available on