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Effect of Poly(3-octylthiophene) Doping on the Attachment and Proliferation of Osteoblasts

✍ Scribed by Charlene Rincón; Chien-Chiang Chen; J. Carson Meredith

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
484 KB
Volume
10
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

The effect of doping P3OT with ferric chloride on the attachment and proliferation of MC3T3‐E1 osteoblasts is reported. Cell density and area correlated strongly with doping concentration: cells were larger and exhibited better spreading as doping increased. Cells cultured on undoped P3OT showed a decrease in proliferation between 24 and 48 h followed by a recovery after 72 h. However, this trend diminished with increasing doping concentration, and disappeared completely at the highest dopant level investigated. Analysis of cell‐cell spatial distributions suggested that contact inhibition of proliferation occurred similarly on both undoped and doped P3OT. From these results, FeCl~3~‐doping had no significant deleterious effect on attachment or proliferation of osteoblasts in vitro.

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