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Orthovanadate both mimics and antagonizes the transforming growth factor β action on normal rat kidney cells

✍ Scribed by Gert Rijksen; Maureen C. W. Völler; Everardus J. J. Van Zoelen

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 985 KB
Volume: 154
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041540223

No coin nor oath required. For personal study only.

✦ Synopsis

Nijmegen (M.C. W.V., EJJ.v.Z.1, The Netherlands Normal rat kidney [NRK] cells grown in thc presence of epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) have a normal phenotype and undergo density-dependent growth inhibition, whereas in the presence of multiple growth factors, density arrest is lost and the cells become phenotypically transformed. We studied the influence of the protein tyrosine phosphatase (PT-

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