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Ortho selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with piperidine

โœ Scribed by Michael D. Wendt; Aaron R. Kunzer


Book ID
108285774
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
427 KB
Volume
51
Category
Article
ISSN
0040-4039

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Ortho-selectivity in SNAr substitutions
โœ Michael D. Wendt; Aaron R. Kunzer ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 431 KB

The nucleophilic addition of organic anions to aromatic compounds with halogens positioned both ortho and para to activating groups was studied in a variety of solvents. Substrates showed strong preferences for ortho substitution in most cases. Evidence is presented for activating group-dependent co